When practical, cleanse the affected area with mild soap and warm water and rinse thoroughly, then gently dry by patting with a soft cloth. Wear gloves to avoid the numbing of the hands and apply a thin layer onto the target area. The numbing effect will take place within 2-3 minutes of application but it is best to leave the product on for 20 minutes. Wipe off the cream completely and cleanse the target area with alcohol pads. The numbing effect will last approximately 1 hour. Numb 520 may be reapplied up to 6 times in a day.